Pathologic complete response in breast cancer patients receiving anthracycline- and taxane-based neoadjuvant chemotherapy
نویسندگان
چکیده
منابع مشابه
Association of tumor infiltration lymphocytes and complete pathological response in breast cancer patients under neoadjuvant chemotherapy
Background: The breast cancer is the most common type of cancer in Iran. Hence determination of the optimal treatment and the contributing factors are important. The main aim in current study was to determine the association between tumor infiltration of lymphocytes (TIL) and complete pathological response in breast cancer patients after neoadjuvant chemotherapy. Methods and materials: In this...
متن کاملTaxane and Anthracycline Based Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer in India
Breast cancer is the most common cancer among females in India, as per urban cancer registries. The Annual Age Adjusted Rate (AAR) varies from 30 per 100,000 in Mumbai to 33.4 per 100,000 in Delhi (Manoharan et al., 2010). LABC refers to large breast tumors (>5 cm) associated with either skin/ chest wall involvement or with fixed axillary lymph nodes or spread to ipsilateral internal mammary or...
متن کاملp53 expression in pretreatment specimen predicts response to neoadjuvant chemotherapy including anthracycline and taxane in patients with primary breast cancer.
While clinical and pathologic responses are important prognostic parameters, biological markers from core needle biopsy (CNB) are needed to predict neoadjuvant chemotherapy (NAC) response, to individualize treatment, and to achieve maximal efficacy. We retrospectively evaluated the cases of 183 patients with primary breast cancer who underwent surgery after NAC (anthracycline and taxane) at the...
متن کاملBiological Markers and Response to Neoadjuvant Taxane-Based Chemotherapy in Patients with Locally Advanced Breast Cancer
Introduction. Biological markers as Her2/neu, p53, and hormonal receptors (HmRs) may be reliable parameters for prognostic assessment of patients of locally advanced breast cancer (LABC). This work aims at assessing the potential value of these biological markers for the prediction of disease outcome after neoadjuvant taxane-based chemotherapy and its implication on the surgical role. Patients ...
متن کاملPrognostic significance of pathologic complete response and Ki67 expression after neoadjuvant chemotherapy in breast cancer.
BACKGROUND Recent studies have indicated that response to chemotherapy and the prognostic impact of a pathologic complete response (pCR) after neoadjuvant chemotherapy differ among breast cancer subtypes. METHODS Women with Stage I to III breast cancer treated with anthracycline and taxane-based neoadjuvant chemotherapy (four cycles of docetaxel every 3 weeks followed by four cycles of FEC ev...
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ژورنال
عنوان ژورنال: Cancer
سال: 2010
ISSN: 0008-543X
DOI: 10.1002/cncr.25296